HCID 3013465, compound → HCID 3013467, compound

HRID 891026Notes

Reaction equation

HRID 891026 reaction equation
[F:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:19]3[CH:18]=[N:17][C:16]([C:20]([O:22]CC)=O)=[CH:15][C:14]=3[C:13]3[C:8]2=[CH:9][CH:10]=[CH:11][CH:12]=3)=[CH:4][CH:3]=1.ClC1C(F)=C(C(F)=CC=1)CN1C2C=NC([C:45]([NH:47][OH:48])=O)=CC=2C2C1=CC=CC=2>>[F:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:19]3[CH:18]=[N:17][C:16]([C:20]([N:47]([OH:48])[CH3:45])=[O:22])=[CH:15][C:14]=3[C:13]3[C:8]2=[CH:9][CH:10]=[CH:11][CH:12]=3)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 3013465HCID 3013465, compoundHCID 21883390HCID 21883390, compound

Product 1

HCID 3013467HCID 3013467, compound

Procedure

The title compound can be prepared from ethyl 9-(4-fluorobenzyl)-9H-β-carboline-3-carboxylate under the similar conditions as those in steps (a) and (b) of example 7. 1H NMR (400 MHz, CD3OD): δ 8.60–8.95 (2H, m), 8.32 (1H, d, J=8 Hz), 7.60–7.75 (2H, m), 6.95–7.45 (5H, m), 5.76 (2H, s), 3.48 (3H, s). HRMS (M+H)+ found: 350.1297. Calcd for C20H17FN3O2: 350.1305.

Sources & evidence

ORD record
ord-1645bcb1f6af44909d29e6951376ffa8
Source dataset
uspto-grants-2006_02
Patent number
US07001912B2

Reaction notes

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