3-Phenyl-2,4-pentanedione → 2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethanol

HRID 891065Notes

Reaction equation

HRID 891065 reaction equation
Cl.[NH:2]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][OH:12])=[CH:6][CH:5]=1)[NH2:3].[C:13]1([CH:19]([C:23](=O)[CH3:24])[C:20](=O)[CH3:21])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[CH3:24][C:23]1[C:19]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:20]([CH3:21])[N:2]([C:4]2[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][OH:12])=[CH:8][CH:9]=2)[N:3]=1

Participants

3

Reactant 2

HCID 2334023-Phenyl-2,4-pentanedioneHCID 222447112-(4-Hydrazinophenyl)ethanol hydrochloride

Product 1

HCID 222446552-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethanol

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 1 from 2-(4-hydrazinophenyl)ethanol hydrochloride and 3-phenylpentane-2,4-dione: MS (ESI) m/z 293 [M+H]+, 1H-NMR (CDCl3) δ 7.45-7.27 (9H, m), 3.79 (2H, t, J=6.6 Hz), 2.87 (2H, t, J=6.6 Hz), 2.32 (3H, s), 2.26 (3H, s).

Sources & evidence

ORD record
ord-dab12e71f30049ef90d229c33eed0160
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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