3-Ethylpentane-2,4-dione → 2-[4-(4-Ethyl-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol

HRID 891067Notes

Reaction equation

HRID 891067 reaction equation
[CH2:1]([CH:3]([C:7](=O)[CH3:8])[C:4](=O)[CH3:5])[CH3:2].Cl.[NH:11]([C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][OH:21])=[CH:15][CH:14]=1)[NH2:12]>>[CH2:1]([C:3]1[C:7]([CH3:8])=[N:12][N:11]([C:13]2[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][OH:21])=[CH:17][CH:18]=2)[C:4]=1[CH3:5])[CH3:2]

Participants

3

Reactant 2

HCID 737613-Ethylpentane-2,4-dioneHCID 222447112-(4-Hydrazinophenyl)ethanol hydrochloride

Product 1

HCID 222446192-[4-(4-Ethyl-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 1 from 3-ethyl-2,4-pentanedione and 2-(4-hydrazinophenyl)ethanol hydrochloride: MS (ESI) m/z 245 [M+H]+, 1H-NMR (CDCl3) δ 7.36-7.26 (4H, m), 3.84 (2H, t, J=6.6 Hz), 2.89 (2H, t, J=6.6 Hz), 2.24 (2H, q, J=7.5 Hz), 2.26 (3H, s), 2.22 (3H, s), 1.12 (3H, t, J=7.5 Hz).

Sources & evidence

ORD record
ord-b047a83665744c8cbae0d318ee2a944d
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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