Sodium Hydroxide → HCID 86759937, compound

HRID 891071Notes

Reaction equation

HRID 891071 reaction equation
[CH2:1]([C:5]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:8]([CH3:16])[N:7]([C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][N:25]([S:29]([C:32]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][CH:33]=3)(=[O:31])=[O:30])[C:26](=[O:28])[O-:27])=[CH:19][CH:18]=2)[N:6]=1)[CH2:2][CH2:3][CH3:4].[OH-].[Na+:40]>CO>[Na+:40].[CH2:1]([C:5]1[C:9]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[C:8]([CH3:16])[N:7]([C:17]2[CH:22]=[CH:21][C:20]([CH2:23][CH2:24][N:25]([S:29]([C:32]3[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][CH:33]=3)(=[O:30])=[O:31])[C:26](=[O:27])[O-:28])=[CH:19][CH:18]=2)[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86759938HCID 86759938, compound

Product 1

HCID 86759937HCID 86759937, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-[4-(3-butyl-5-methyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl(4-methylphenyl)sulfonylcarbamate (step 3, 14 mg, 0.026 mmol) in methanol (10 mL) was added 2 M aqueous NaOH (13 μL, 0.026 mmol). The resulting mixture was stirred at room temperature for 30 min and concentrated to afford the title compound as white solids: MS (ESI) m/z 532 [M+H]+, 530 [M−H]−.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-2260e26cd5f54003a23580cb28518cdd
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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