4-Ethoxyphenylboronic acid → HCID 22244610, compound

HRID 891084Notes

Reaction equation

I[C:2]1[C:3]([CH3:17])=[N:4][N:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=2)[C:6]=1[CH3:7].[CH2:18]([O:20][C:21]1[CH:26]=[CH:25][C:24](B(O)O)=[CH:23][CH:22]=1)[CH3:19]>>[CH2:18]([O:20][C:21]1[CH:26]=[CH:25][C:24]([C:2]2[C:3]([CH3:17])=[N:4][N:5]([C:8]3[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=3)[C:6]=2[CH3:7])=[CH:23][CH:22]=1)[CH3:19]

Participants

Reactant 2

HCID 27343514-Ethoxyphenylboronic acid

HCID 222445592-[4-(4-Iodo-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol

Product 1

HCID 22244610HCID 22244610, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 12 from 2-[4-(4-iodo-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol (step 2 of Example 11) and 4-ethoxybenzene boronic acid: MS (ESI) m/z 337 [M+H]+, 1H-NMR (CDCl3) δ 7.43 (2H, d, J=8.6 Hz), 7.33 (2H, d, J=8.6 Hz), 7.24 (2H, d, J=8.7 Hz), 6.98 (2H, d, J=8.7 Hz), 4.08 (2H, q, J=6.9 Hz), 3.91-3.89 (2H, m), 2.93 (2H, t, J=6.6 Hz), 2.31 (3H, s), 2.28 (3H, s), 1.45 (3H, t, J=6.9 Hz).

Sources & evidence

ORD record: ord-9f3b0ff1822144778af2b381884b4f8a
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07001917B2

Reaction notes

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