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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 891094Generated: October 31, 2026

4-(Trifluoromethoxy)benzenesulfonamide → N-[({2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]-4-[(trifluoromethyl)oxy]benzenesulfonamide

https://huagongshe.com/reaction/891094

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-(Trifluoromethoxy)benzenesulfonamideHCID 2777211—
ReactantPhenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamateHCID 22244550—
ProductN-[({2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]-4-[(trifluoromethyl)oxy]benzenesulfonamideHCID 10289728—

Reaction Steps

The title compound was prepared according to the procedure described in step 2 of Example 22 from phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22) and 4-[(trifluoromethyl)oxy]benzenesulfonamide: 1H-NMR (CDCl3) δ 7.98 (2H, d, J=9.1 Hz), 7.47-7.21 (11H, m), δ 12 (1H, br.s), 3.50-3.43 (2H, m), 2.85 (2H, t, J=6:5 Hz). 2.32 (3H, s), 2.23 (3H, s).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07001917B2
Source datasetuspto-grants-2006_02
ORD IDord-01f22edab81141a88b0fd128b2f72ae4
Source noteuspto-grants-2006_02