2-Hydroxybenzene-1-sulfonamide → HCID 22244556, compound

HRID 891109Notes

Reaction equation

HRID 891109 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=O)[O:24]C3C=CC=CC=3)=[CH:16][CH:15]=2)[N:3]=1.[OH:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[S:39]([NH2:42])(=[O:41])=[O:40]>>[CH3:1][C:2]1[C:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:15]=[CH:16][C:17]([CH2:20][CH2:21][NH:22][C:23]([NH:42][S:39]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=3[OH:32])(=[O:40])=[O:41])=[O:24])=[CH:18][CH:19]=2)[N:3]=1

Participants

3

Reactant 2

HCID 6375462-Hydroxybenzene-1-sulfonamideHCID 22244550Phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate

Product 1

HCID 22244556HCID 22244556, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22) and 2-hydroxybenzenesulfonamide [Synth. Commun., 1994, 24, 671]: 1H-NMR (CDCl3) δ 7.74-7.70 (1H, m), 7.48-7.24 (9H, m), 7.15 (2H, d, J=8.2 Hz), 7.02 (1H, d, J=7.7 Hz), 6.93 (1H, t, J=7.6 Hz), 6.16 (1H, br.s), 3.47-3.40 (2H, m), 2.81 (2H, t, J=6.5 Hz), 2.32 (3H, s), 2.23 (3H, s).

Sources & evidence

ORD record
ord-b9e97434574d41e3baf9314dc2cd451a
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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