2,6-Difluorobenzenesulfonamide → N-[({2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]-2,6-difluorobenzenesulfonamide

HRID 891115Notes

Reaction equation

HRID 891115 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=O)[O:24]C3C=CC=CC=3)=[CH:16][CH:15]=2)[N:3]=1.[F:32][C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([F:39])[C:34]=1[S:40]([NH2:43])(=[O:42])=[O:41]>>[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23]([NH:43][S:40]([C:34]3[C:35]([F:39])=[CH:36][CH:37]=[CH:38][C:33]=3[F:32])(=[O:41])=[O:42])=[O:24])=[CH:16][CH:15]=2)[N:3]=1

Participants

3

Reactant 2

HCID 4462742,6-DifluorobenzenesulfonamideHCID 22244550Phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate

Product 1

HCID 22244553N-[({2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]-2,6-difluorobenzenesulfonamide

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22) and 2,6-difluorobenzenesulfonamide: 1H-NMR (CDCl3) δ 7.44-7.19 (10H, m), 6.93 (2H, t, J=9.0 Hz), 6.52 (1H, br.s), 3.39-3.37 (2H, m), 2.79-2.74 (2H, m), 2.29 (3H, s), 2.20 (3H, s).

Sources & evidence

ORD record
ord-b1ac2090453d4defb9ccec4b2d0b16ed
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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