3-Sulfamoylbenzamide → 3-({[({2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino) carbonyl]amino}sulfonyl)benzamide

HRID 891123Notes

Reaction equation

HRID 891123 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=[O:31])OC3C=CC=CC=3)=[CH:16][CH:15]=2)[N:3]=1.[NH2:32][S:33]([C:36]1[CH:37]=[C:38]([CH:42]=[CH:43][CH:44]=1)[C:39]([NH2:41])=[O:40])(=[O:35])=[O:34]>>[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:15]=[CH:16][C:17]([CH2:20][CH2:21][NH:22][C:23]([NH:32][S:33]([C:36]3[CH:37]=[C:38]([CH:42]=[CH:43][CH:44]=3)[C:39]([NH2:41])=[O:40])(=[O:34])=[O:35])=[O:31])=[CH:18][CH:19]=2)[N:3]=1

Participants

3

Reactant 2

HCID 136682503-SulfamoylbenzamideHCID 22244550Phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate

Product 1

HCID 222447023-({[({2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino) carbonyl]amino}sulfonyl)benzamide

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22) and 3-(aminosulfonyl)benzamide: 1H-NMR (CDCl3) δ 8.47 (1H, s), 8.01 (2H, d, J=8.9 Hz), 7.60-7.11 (10H, m), 6.70 (1H, br.s), 6.30 (1H, br.s), 3.38-3.35 (2H, m), 2.77-2.71 (2H, m), 2.29 (3H, s), 2.17 (3H, s).

Sources & evidence

ORD record
ord-8ddaa57abf7b4c62b1d74e21b6d9491c
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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