1,3-BENZENEDISULFONAMIDE → HCID 22244705, compound

HRID 891135Notes

Reaction equation

HRID 891135 reaction equation
[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][NH:15][C:16](=O)[O:17]C3C=CC=CC=3)=[CH:9][CH:8]=2)[N:5]=[C:4]([C:25]([F:28])([F:27])[F:26])[C:3]=1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1.[C:35]1([S:45]([NH2:48])(=[O:47])=[O:46])[CH:40]=[CH:39][CH:38]=[C:37]([S:41]([NH2:44])(=[O:43])=[O:42])[CH:36]=1>>[CH3:1][C:2]1[N:6]([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][NH:15][C:16]([NH:44][S:41]([C:37]3[CH:38]=[CH:39][CH:40]=[C:35]([S:45]([NH2:48])(=[O:47])=[O:46])[CH:36]=3)(=[O:43])=[O:42])=[O:17])=[CH:9][CH:8]=2)[N:5]=[C:4]([C:25]([F:26])([F:27])[F:28])[C:3]=1[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 30900441,3-BENZENEDISULFONAMIDEHCID 22244671Phenyl 2-{4-[5-methyl-4-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethylcarbamate

Product 1

HCID 22244705HCID 22244705, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-{4-[5-methyl-4-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethylcarbamate (step 7 of Example 52) and 1,3-benzenedisulfonamide: MS (ESI) m/z 608 [M+H]+, 606 [M−H]−, 1H-NMR (CDCl3) δ 8.62 (1H, br.s), 8.14 (2H, br.s), 7.70 (1H, br.s), 7.39-7.21 (9H, m), 6.18 (1H, br.s), 3.35 (2H, br.s), 2.76 (2H, br.s), 2.15 (3H, s).

Sources & evidence

ORD record
ord-9d04157716094c248ca7954ddfa18105
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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