N-((4-(Aminosulphonyl)phenyl)methyl)acetamide → N-[4-({[({2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]amino}sulfonyl)benzyl]acetamide

HRID 891141Notes

Reaction equation

HRID 891141 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=O)[O:24]C3C=CC=CC=3)=[CH:16][CH:15]=2)[N:3]=1.[NH2:32][S:33]([C:36]1[CH:46]=[CH:45][C:39]([CH2:40][NH:41][C:42](=[O:44])[CH3:43])=[CH:38][CH:37]=1)(=[O:35])=[O:34]>>[CH3:1][C:2]1[C:6]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:15]=[CH:16][C:17]([CH2:20][CH2:21][NH:22][C:23]([NH:32][S:33]([C:36]3[CH:37]=[CH:38][C:39]([CH2:40][NH:41][C:42](=[O:44])[CH3:43])=[CH:45][CH:46]=3)(=[O:34])=[O:35])=[O:24])=[CH:18][CH:19]=2)[N:3]=1

Participants

3

Reactant 2

HCID 74833N-((4-(Aminosulphonyl)phenyl)methyl)acetamideHCID 22244550Phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate

Product 1

HCID 22244693N-[4-({[({2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]amino}sulfonyl)benzyl]acetamide

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22) and N-[4-(aminosulfonyl)benzyl]acetamide: 1H-NMR [CDCl3/CD3OD(4:1)]δ 7.90-7.87 (2H, m), 7.48-7.26 (11H, m), 4.44 (2H, s), 3.45-3.41 (2H, m), 2.87-2.82 (2H, m), 2.32 (3H, s), 2.27 (3H, s), 2.03 (3H, s).

Sources & evidence

ORD record
ord-fd2881f7589a4f2b95a60739d736656d
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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