pyridine-3-sulfonamide → N-{[(2-{4-[5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethyl)amino]carbonyl}pyridine-3-sulfonamide

HRID 891148Notes

Reaction equation

HRID 891148 reaction equation
[C:1]1([C:7]2[N:11]([C:12]3[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][NH:20][C:21](=O)[O:22]C4C=CC=CC=4)=[CH:14][CH:13]=3)[N:10]=[C:9]([C:30]([F:33])([F:32])[F:31])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N:34]1[CH:39]=[CH:38][CH:37]=[C:36]([S:40]([NH2:43])(=[O:42])=[O:41])[CH:35]=1>>[C:1]1([C:7]2[N:11]([C:12]3[CH:13]=[CH:14][C:15]([CH2:18][CH2:19][NH:20][C:21]([NH:43][S:40]([C:36]4[CH:35]=[N:34][CH:39]=[CH:38][CH:37]=4)(=[O:42])=[O:41])=[O:22])=[CH:16][CH:17]=3)[N:10]=[C:9]([C:30]([F:33])([F:32])[F:31])[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 232710pyridine-3-sulfonamideHCID 22244661HCID 22244661, compound

Product 1

HCID 22244518N-{[(2-{4-[5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethyl)amino]carbonyl}pyridine-3-sulfonamide

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 0.42 from phenyl 2-{4-[5-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethylcarbamate (step 4) and pyridine-3-sulfonamide: 1H-NMR (CDCl3) δ 9.04 (1H, d, J=2.0 Hz), 8.78 (1H, d, J=3.7 Hz), 8.08-8.04 (1H, m), 7.48-7.44 (1H, m), 7.34-7.10 (9H, m), 6.76 (1H, s), 6.28 (1H, br.s), 3.48-3.42 (2H, m), 2.83-2.78 (2H, m).

Sources & evidence

ORD record
ord-9323689b780b4c2181a430f09c9f4220
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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