4-Chlorobenzenesulfonamide → 4-chloro-N-[({2-[6-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)pyridin-3-yl]ethyl}amino)carbonyl]benzenesulfonamide

HRID 891156Notes

Reaction equation

HRID 891156 reaction equation
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[N:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=O)[O:24]C3C=CC=CC=3)=[CH:16][CH:15]=2)[N:3]=1.[Cl:32][C:33]1[CH:38]=[CH:37][C:36]([S:39]([NH2:42])(=[O:41])=[O:40])=[CH:35][CH:34]=1>>[Cl:32][C:33]1[CH:34]=[CH:35][C:36]([S:39]([NH:42][C:23]([NH:22][CH2:21][CH2:20][C:17]2[CH:18]=[N:19][C:14]([N:4]3[C:5]([CH3:13])=[C:6]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=4)[C:2]([CH3:1])=[N:3]3)=[CH:15][CH:16]=2)=[O:24])(=[O:40])=[O:41])=[CH:37][CH:38]=1

Participants

3

Reactant 2

HCID 668244-ChlorobenzenesulfonamideHCID 22244603phenyl 2-[6-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)pyridin-3-yl]ethylcarbamate

Product 1

HCID 222446544-chloro-N-[({2-[6-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)pyridin-3-yl]ethyl}amino)carbonyl]benzenesulfonamide

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-[6-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)pyridin-3-yl]ethylcarbamate (step 5) and 4-chlorobenzenesulfonamide: 1H-NMR (CDCl3) δ 8.20 (1H, br.s), 7.83-7.77 (22H, m), 7.63-7.26 (9H, m), 6.68 (1H, br.s), 3.52-3.45 (2H, m), 2.84-2.79 (2H, m), 2.48 (3H, s), 2.67 (3H, s).

Sources & evidence

ORD record
ord-6f33020fbdd243239ceb22cd0e14dae9
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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