(4-Methoxyphenyl)boronic acid → HCID 22244523, compound

HRID 891164Notes

Reaction equation

HRID 891164 reaction equation
I[C:2]1[C:3]([CH3:17])=[N:4][N:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=2)[C:6]=1[CH3:7].[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1>>[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([C:2]2[C:3]([CH3:17])=[N:4][N:5]([C:8]3[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=3)[C:6]=2[CH3:7])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 201262(4-Methoxyphenyl)boronic acidHCID 222445592-[4-(4-Iodo-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol

Product 1

HCID 22244523HCID 22244523, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 12 from 2-[4-(4-iodo-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol (step 2 of Example 11) and 4-methoxyphenylboronic acid: MS (ESI) m/z 323 [M+H]+H-NMR (CDCl3) δ 7.39 (2H, d, J=8.1 Hz), 7.29-7.22 (4H, m), 6.98 (2H, d, J=9.6 Hz), 3.86 (3H, s), 3.74 (2H, br), 2.86 (2H, t, J=6.6 Hz), 2.33 (3H, s), 2.28 (3H, s).

Sources & evidence

ORD record
ord-7c2556bf5e5b47c29325419daa169cef
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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