2-(Tributylstannyl)-1,3-thiazole → 2-{4-[3,5-Dimethyl-4-(1,3-thiazol-2-yl)-1H-pyrazol-1-yl]phenyl}ethanol

Participants

Reaction Steps

A mixture of 2-[4-(4-iodo-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol (step 2 of Example 11) (855 mg, 2.5 mmol), 2-tributylstannylthiazole (3 mmol) and tetrakistriphenylophosphinepalladium (346 mg, 0.3 mol) in m-xylene (6 mL) was refluxed for 16 h. The mixture was filtered through a pad of Celite and the filtrate was concentrated. The crude product was purified by TLC with hexane/ethyl acetate (1:1) to afford 39 mg (5%) of the title compound as yellow oil: MS (EI) m/z 299 [M]+.

Provenance & Evidence