Pivaloyl chloride → HCID 22244531, compound

HRID 891166Notes

Reaction equation

HRID 891166 reaction equation
[C:1]([Mg]Br)#[C:2][CH3:3].[C:6](Cl)(=O)[C:7]([CH3:10])([CH3:9])[CH3:8].Cl.[NH:14]([C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][OH:24])=[CH:18][CH:17]=1)[NH2:15]>>[C:7]([C:6]1[CH:1]=[C:2]([CH3:3])[N:14]([C:16]2[CH:17]=[CH:18][C:19]([CH2:22][CH2:23][OH:24])=[CH:20][CH:21]=2)[N:15]=1)([CH3:10])([CH3:9])[CH3:8]

Participants

4

Reactant 3

HCID 62493Pivaloyl chlorideHCID 222447112-(4-Hydrazinophenyl)ethanol hydrochlorideHCID 178419101HCID 178419101, compound

Product 1

HCID 22244531HCID 22244531, compound

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 63 from propynylmagnesium bromide, pivaloyl chloride and 2-(4-hydrazinophenyl)ethanol hydrochloride: MS (EI) m/z 334 [M]+, 1H-NMR (CDCl3) δ 7.39-7.29 (4H, m), 6.05 (1H, s), 3.85 (2H, m), 2.90 (2H, m), 2.30 (3H, s), 1.60 (1H, br.s), 1.33 (9H, s).

Sources & evidence

ORD record
ord-c0aee305bd114c00a4acc31d7b398fbb
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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