5-Bromo-1,2,3-trimethoxybenzene → HCID 178418846, compound

HRID 891174Notes

Reaction equation

HRID 891174 reaction equation
C([Li:5])CCC.[CH3:6][O:7][C:8]1[CH:9]=[C:10](Br)[CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15]>CCOCC>[CH3:6][O:7][C:8]1[CH:9]=[C:10]([Li:5])[CH:11]=[C:12]([O:16][CH3:17])[C:13]=1[O:14][CH3:15]

Participants

4

Reactant 2

HCID 758855-Bromo-1,2,3-trimethoxybenzeneHCID 178418339Butyllithium

Product 1

HCID 178418846HCID 178418846, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a stirred solution of n-butyllithium (15.0 mL, 1.6 M in hexane solution, 24.0 mol) in dry ether (160 mL), a solution of 3,4,5-trimethoxyphenylbromide (2.97 g, 12.0 mol) in ether (40 mL) was added under dry nitrogen at −78° C. The solution was stirred for 1 h in order to form 3,4,5-trimethoxyphenyllithum.

Sources & evidence

ORD record
ord-4ff7310d724d4c008e135c9ee2ecac5a
Source dataset
uspto-grants-2006_02
Patent number
US07001926B2

Reaction notes

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