Trifluoroacetic acid → HCID 23598687, compound

HRID 891196Notes

Reaction equation

HRID 891196 reaction equation
[CH3:1][O:2][C:3](=[O:30])[CH2:4][N:5]1[CH2:11][C:10]([C:12](C)(C)[O:13][SiH2]C(C)(C)C)=[CH:9][CH2:8][CH:7]([NH:21]C(OC(C)(C)C)=O)[C:6]1=[O:29].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:30])[CH2:4][N:5]1[CH2:11][C:10]([CH2:12][OH:13])=[CH:9][CH2:8][CH:7]([NH2:21])[C:6]1=[O:29]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131725289HCID 131725289, compound

Product 1

HCID 23598687HCID 23598687, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of [3-tert-Butoxycarbonylamino-6-(tert-butyl-dimethyl-silanyloxymethyl)-oxo-2,3,4,7-tetrahydro-azepin-1-yl]-acetic acid methyl ester, 17, (4.32 g, 9.7 mmol) in CH2Cl2 (20 mL) is treated with wet TFA (5 mL) and stirred at rt for 30 min. The solution is concentrated in vacuo using toluene to azeotrope off the solvent. The crude product is used without further purification.

Workup

  1. concentrationThe solution is concentrated in vacuo
  2. customThe crude product is used without further purification

Sources & evidence

ORD record
ord-6318c8cc75794989b336a782f442de34
Source dataset
uspto-grants-2006_02
Patent number
US07001899B2

Reaction notes

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