Lithium Hydroxide → HCID 22243177, compound

Participants

Reaction Steps

A solution containing {6-(benzoylamino-methyl)-3-[(isoquinoline-1-carbonyl)-amino]-2-oxo-2,3,4,7-tetrahydro-azepin-1-yl}-acetic acid methyl ester, 30, (84 mg, 0.17 mmol) in THF/H2O (4 mL of 3:1) is treated with excess LiOH and the solution stirred for 2.5 hours at room temperature. The solution is then acidified and extracted with EtOAc. The EtOAc layer was dried (Na2SO4) and concentrated to the crude product which is used without further purification.

Provenance & Evidence