Lithium Hydroxide → HCID 22243177, compound

HRID 891206Notes

Reaction equation

HRID 891206 reaction equation
C[O:2][C:3](=[O:36])[CH2:4][N:5]1[CH2:11][C:10]([CH2:12][NH:13][C:14](=[O:21])[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:9][CH2:8][CH:7]([NH:22][C:23]([C:25]2[C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:28]=[CH:27][N:26]=2)=[O:24])[C:6]1=[O:35].[Li+].[OH-]>C1COCC1.O>[C:14]([NH:13][CH2:12][C:10]1[CH2:11][N:5]([CH2:4][C:3]([OH:36])=[O:2])[C:6](=[O:35])[CH:7]([NH:22][C:23]([C:25]2[C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:28]=[CH:27][N:26]=2)=[O:24])[CH2:8][CH:9]=1)(=[O:21])[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 23598691HCID 23598691, compound

Product 1

HCID 22243177HCID 22243177, compound

Reagents, catalysts & solvents 1

HCID 21881883Oxolane--water (1/1)Solvent

Procedure

A solution containing {6-(benzoylamino-methyl)-3-[(isoquinoline-1-carbonyl)-amino]-2-oxo-2,3,4,7-tetrahydro-azepin-1-yl}-acetic acid methyl ester, 30, (84 mg, 0.17 mmol) in THF/H2O (4 mL of 3:1) is treated with excess LiOH and the solution stirred for 2.5 hours at room temperature. The solution is then acidified and extracted with EtOAc. The EtOAc layer was dried (Na2SO4) and concentrated to the crude product which is used without further purification.

Workup

  1. extractionextracted with EtOAc
  2. dry with materialThe EtOAc layer was dried (Na2SO4)
  3. concentrationconcentrated to the crude product which
  4. customis used without further purification

Sources & evidence

ORD record
ord-d02ab2fc3552482692a43f142d8a1864
Source dataset
uspto-grants-2006_02
Patent number
US07001899B2

Reaction notes

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