Neopentyl alcohol → HCID 21934264, compound

HRID 891396Notes

Reaction equation

[F:1][C:2]([F:21])([F:20])[CH2:3][N:4]1[C:9](=[O:10])[C:8]([OH:11])=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=2)[CH:6]=[N:5]1.[CH3:22][C:23]([CH3:27])([CH3:26])[CH2:24]O>>[F:21][C:2]([F:1])([F:20])[CH2:3][N:4]1[C:9](=[O:10])[C:8]([O:11][CH2:22][C:23]([CH3:27])([CH3:26])[CH3:24])=[C:7]([C:12]2[CH:17]=[CH:16][C:15]([S:18][CH3:19])=[CH:14][CH:13]=2)[CH:6]=[N:5]1

Participants

Reactant 2

HCID 6404Neopentyl alcohol

HCID 178503118HCID 178503118, compound

Product 1

HCID 21934264HCID 21934264, compound

Procedure

The intermediate, 2-(2,2,2-trifluoroethyl)-4-hydroxy-5-[4-(methylthio)phenyl]-3(2H)-pyridazinone prepared in Example 90C was reacted with 2,2-dimethylpropanol to provide 2-(2,2,2-trifluoroethyl)-4-(2,2-dimethylpropoxy)-5-[4-(methylthio)phenyl]-3(2H)-pyridazinone according to the method of Example 90D.

Sources & evidence

ORD record: ord-1795f6cb2fea4be5914d5d5e11adddbb
Source dataset: uspto-grants-2006_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07001895B2

Reaction notes

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