Pyridine → HCID 69663720, compound

HRID 891472Notes

Reaction equation

HRID 891472 reaction equation
[N:1]1C=CC=[CH:3][CH:2]=1.[C:7]([O:10][C:11](=[O:13])C)(=[O:9])[CH3:8]>C(Cl)Cl>[C:2]([NH2:1])(=[O:9])[CH3:3].[O:10]1[CH2:7][CH2:8][NH:1][C:11]1=[O:13]

Participants

4

Reactant 2

HCID 1049PyridineHCID 7918Acetic Anhydride

Product 1

HCID 69663720HCID 69663720, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Acetylation of Oxazolidinone Amine. To the crude oxazolidinone amine residue 16a in DCM at room temperature was added pyridine (30 equivalents) and acetic anhydride (20 equivalents). The solution was stirred for 2 hrs and concentrated in vacua. The oxazolidinone acetamide residue was purified by HPLC to provide pure oxazolidinone acetamide.

Workup

  1. concentrationconcentrated in vacua
  2. customThe oxazolidinone acetamide residue was purified by HPLC

Sources & evidence

ORD record
ord-9b51ff5f973e4be08c0702b766e1f326
Source dataset
uspto-grants-2006_02
Patent number
US07002020B1

Reaction notes

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