Dichloromethane → 4-(4-Fluorophenyl)-2-((5-methylisoxazol-3-yl)methyl)-2,7-diazaspiro[4.5]decan-1-one

HRID 89163Notes

Reaction equation

HRID 89163 reaction equation
[Cl:40][CH2:41][Cl:42].[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][N:10]([CH2:26][c:27]3[n:28][o:29][c:30]([CH3:32])[cH:31]3)[C:11](=[O:25])[C:12]23[CH2:13][N:14]([C:18]([O:19][C:20]([CH3:21])([CH3:22])[CH3:23])=[O:24])[CH2:15][CH2:16][CH2:17]3)[cH:6][cH:7]1.[OH:33][C:34]([C:35]([F:36])([F:37])[F:38])=[O:39]>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH2:9][N:10]([CH2:26][c:27]3[n:28][o:29][c:30]([CH3:32])[cH:31]3)[C:11](=[O:25])[C:12]23[CH2:13][NH:14][CH2:15][CH2:16][CH2:17]3)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 71060659Tert-butyl 4-(4-fluorophenyl)-2-((5-methylisoxazol-3-yl)methyl)-1-oxo-2,7-diazaspiro[4.5]decane-7-carboxylate

Product 1

HCID 710604374-(4-Fluorophenyl)-2-((5-methylisoxazol-3-yl)methyl)-2,7-diazaspiro[4.5]decan-1-one

Sources & evidence

ORD record
ord-8eedc102723b46559f7b3aaf9fa6be6e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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