Hydrochloric Acid → HCID 69544172, compound

HRID 891704Notes

Reaction equation

HRID 891704 reaction equation
[N+:1]([C:4]1[CH:25]=[CH:24][C:7]([CH2:8][O:9][C:10](=[O:23])[CH2:11][N:12](C(OC(C)(C)C)=O)[CH:13]([CH3:15])[CH3:14])=[CH:6][CH:5]=1)([O-:3])=[O:2].[ClH:26].C(OCC)C>O1CCOCC1>[ClH:26].[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:8][O:9][C:10](=[O:23])[CH2:11][NH:12][CH:13]([CH3:14])[CH3:15])=[CH:24][CH:25]=1)([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 69544177HCID 69544177, compound

Product 1

HCID 69544172HCID 69544172, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of (N-t-butoxycarbonyl-N-isopropyl-amino)-acetic acid p-nitrobenzyl ester (1.93 g, 5.48 mmol) in 1,4-dioxane (20 ml) was added a solution of 4N hydrogen chloride in 1,4-dioxane (20 ml) in an ice bath, and the mixture was stirred at room temperature overnight. After checking the completion of the reaction, diethyl ether was added thereto the reaction mixture was stirred for 30 minutes and filtered, and the obtained residue was washed with diethyl ether and dried to give (isopropylamino)acetic acid p-nitrobenzyl ester hydrochloride (1.50 g, yield 95%) as white crystals.

Workup

  1. additionwas added
  2. stirringthe reaction mixture was stirred for 30 minutes
  3. filtrationfiltered
  4. washthe obtained residue was washed with diethyl ether
  5. customdried

Sources & evidence

ORD record
ord-eb5fdd11b0704505bd64da5c4e64dd6a
Source dataset
uspto-grants-2006_02
Patent number
US07001897B2

Reaction notes

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