Hydrochloric Acid → N~2~-Propan-2-ylglycinamide--hydrogen chloride (1/1)

HRID 891706Notes

Reaction equation

HRID 891706 reaction equation
C(OC(=O)[N:7]([CH2:11][C:12](=[O:14])[NH2:13])[CH:8]([CH3:10])[CH3:9])(C)(C)C.[ClH:16].C(OCC)C>O1CCOCC1>[ClH:16].[CH:8]([NH:7][CH2:11][C:12]([NH2:13])=[O:14])([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 62544165HCID 62544165, compound

Product 1

HCID 16243660N~2~-Propan-2-ylglycinamide--hydrogen chloride (1/1)Yield 97%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of N-carbamoylmethyl-N-isopropyl-carbamic acid t-butyl ester (2.67 g, 12.3 mmol) (obtained as described in Reference Example 49(1)) in 1,4-dioxane (30 ml) was added a solution of 4N hydrogen chloride in 1,4-dioxane (30 ml) in an ice bath, and then the mixture was stirred at room temperature overnight. After checking the completion of the reaction, diethyl ether was added thereto and the reaction mixture was stirred for 30 minutes. The resulting mixture was filtered, and the residue was washed with diethyl ether and then dried under reduced pressure to give 2-isopropylaminoacetamide hydrochloride (1.82 g, yield 97%) as white crystals.

Workup

  1. additionwas added
  2. stirringthe reaction mixture was stirred for 30 minutes
  3. filtrationThe resulting mixture was filtered
  4. washthe residue was washed with diethyl ether
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-579c2296d911401ebe0bc54fd581ec40
Source dataset
uspto-grants-2006_02
Patent number
US07001897B2

Reaction notes

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