反应详情

To a solution of 3-benzoyloxy-1-(4-methoxycarbonyl-1,3-oxazol-2-yl)azetidine (5.24 g, 17.3 mmol) (obtained as described in Reference Example 70(6)) in a mixture of methanol (260 ml) and methylene chloride (80 ml) was added a catalytic amount of sodium methoxide at room temperature and the mixture was stirred for 1 hour. After checking the completion of the reaction, the mixture was neutralized with 4 N hydrogen chloride gas in dioxane and concentrated under reduced pressure. The residue was purified by chromatography on a silica gel column using methylene chloride:methanol (95:5) as the eluant to afford 3-hydroxy-1-(4-methoxycarbonyl-1,3-oxazol-2-yl)azetidine (2.65 g, yield 77%) as pale brown crystals.

1. customthe completion of the reaction
2. concentrationconcentrated under reduced pressure
3. customThe residue was purified by chromatography on a silica gel column