反应详情

温度

80 °C

To a solution of 1-[4-(3-t-butyldiphenylsilyloxyazetidine-1-carbonyl)-1,3-oxazol-2-yl]-3-methanesulfonyloxyazetidine (1.56 g, 2.81 mmol) (obtained as described in Reference Example 74(2)) in dimethylformamide (80 ml) was added potassium thioacetate (1.92 g, 16.8 mmol) at room temperature and the mixture was stirred in an oil bath (80° C.) for 7.5 hours. After checking the completion of the reaction, the mixture was partitioned between ethyl acetate and 10% aqueous sodium chloride solution. The organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and saturated aqueous sodium chloride solution, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by chromatography on a silica gel column using n-hexane:ethyl acetate (2:1→1:1) as the eluant to afford 3-acetylthio-1-[4-(3-t-butyldiphenylsilyloxyazetidine-1-carbonyl)-1,3-oxazol-2-yl]azetidine (863 mg, yield 57%) as a pale brown solid.

1. customat room temperature
2. customthe completion of the reaction
3. customthe mixture was partitioned between ethyl acetate and 10% aqueous sodium chloride solution
4. washThe organic layer was washed with saturated aqueous sodium hydrogencarbonate solution and saturated aqueous sodium chloride solution
5. dry with materialdried over anhydrous sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated under reduced pressure
8. customThe residue was purified by chromatography on a silica gel column