3-(Trifluoromethyl)phenylboronic acid → 3-(2-Methyl-imidazol-1-yl-methyl)-5-(3-trifluoromethyl-phenyl)-pyridazine Hydrochloride

HRID 891875Notes

Reaction equation

HRID 891875 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][CH:8]=1.[Cl:14][C:15]1[CH:16]=[C:17]([CH2:21][N:22]2[CH:26]=[CH:25][N:24]=[C:23]2[CH3:27])[N:18]=[N:19][CH:20]=1>>[ClH:14].[CH3:27][C:23]1[N:22]([CH2:21][C:17]2[N:18]=[N:19][CH:20]=[C:15]([C:5]3[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:13])([F:12])[F:1])[CH:4]=3)[CH:16]=2)[CH:26]=[CH:25][N:24]=1

Participants

3

Reactant 2

HCID 27343883-(Trifluoromethyl)phenylboronic acidHCID 117890255-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine

Product 1

HCID 222401543-(2-Methyl-imidazol-1-yl-methyl)-5-(3-trifluoromethyl-phenyl)-pyridazine Hydrochloride

Procedure

The title compound, MS: m/e=319.4 (M+H+), was prepared from 3-trifluoromethylbenzeneboronic acid (commercially available) and 5-chloro-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine.

Sources & evidence

ORD record
ord-9462ab83ebd44f918ecd2c85fb29569e
Source dataset
uspto-grants-2006_02
Patent number
US07005432B2

Reaction notes

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