5-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine → 5-(3-Difluoromethyl-phenyl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine Hydrochloride

HRID 891896Notes

Reaction equation

HRID 891896 reaction equation
[F:1][CH:2]([F:18])[C:3]1[CH:4]=[C:5](B2OC(C)(C)C(C)(C)O2)[CH:6]=[CH:7][CH:8]=1.[Cl:19][C:20]1[CH:21]=[C:22]([CH2:26][N:27]2[CH:31]=[CH:30][N:29]=[C:28]2[CH3:32])[N:23]=[N:24][CH:25]=1>>[ClH:19].[F:18][CH:2]([F:1])[C:3]1[CH:4]=[C:5]([C:20]2[CH:21]=[C:22]([CH2:26][N:27]3[CH:31]=[CH:30][N:29]=[C:28]3[CH3:32])[N:23]=[N:24][CH:25]=2)[CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 117890255-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazineHCID 222401672-(3-(Difluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product 1

HCID 222402865-(3-Difluoromethyl-phenyl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine Hydrochloride

Procedure

The title compound, MS: m/e=301.3 (M+H+), was prepared from 2-(3-difluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane and 5-chloro-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine.

Sources & evidence

ORD record
ord-9c5d0845a8984f1a9ccbb5b17f2acc5e
Source dataset
uspto-grants-2006_02
Patent number
US07005432B2

Reaction notes

Loading…