5-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine → 5-[3-(1,1-Difluoro-ethyl)-5-fluoro-phenyl]-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine Hydrochloride

HRID 891902Notes

Reaction equation

HRID 891902 reaction equation
[F:1][C:2]([C:5]1[CH:6]=[C:7](B2OC(C)(C)C(C)(C)O2)[CH:8]=[C:9]([F:11])[CH:10]=1)([F:4])[CH3:3].[Cl:21][C:22]1[CH:23]=[C:24]([CH2:28][N:29]2[CH:33]=[CH:32][N:31]=[C:30]2[CH3:34])[N:25]=[N:26][CH:27]=1>>[ClH:21].[F:4][C:2]([C:5]1[CH:6]=[C:7]([C:22]2[CH:23]=[C:24]([CH2:28][N:29]3[CH:33]=[CH:32][N:31]=[C:30]3[CH3:34])[N:25]=[N:26][CH:27]=2)[CH:8]=[C:9]([F:11])[CH:10]=1)([F:1])[CH3:3]

Participants

3

Reactant 2

HCID 117890255-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazineHCID 222401282-(3-(1,1-Difluoroethyl)-5-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product 1

HCID 222402515-[3-(1,1-Difluoro-ethyl)-5-fluoro-phenyl]-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine Hydrochloride

Procedure

The title compound, MS: m/e=333.3 (M+H+), was prepared from 2-[3-(1,1-difluoro-ethyl)-5-fluoro-phenyl]-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane and 5-chloro-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine.

Sources & evidence

ORD record
ord-09544736909c455ba5ebb9e997314ee1
Source dataset
uspto-grants-2006_02
Patent number
US07005432B2

Reaction notes

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