3-(4-methoxybenzyl)-1H-pyrazol-5-amine → 3-[[[5-[(4-methoxyphenyl)methyl]-1H-pyrazol-3-yl]amino]methylidene]-1H-indol-2-one

HRID 892018Notes

Reaction equation

HRID 892018 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[CH3:19][O:20][C:21]1[CH:33]=[CH:32][C:24]([CH2:25][C:26]2[NH:30][N:29]=[C:28]([NH2:31])[CH:27]=2)=[CH:23][CH:22]=1>O1CCCC1>[CH3:19][O:20][C:21]1[CH:22]=[CH:23][C:24]([CH2:25][C:26]2[NH:30][N:29]=[C:28]([NH:31][CH:8]=[C:9]3[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[NH:11][C:10]3=[O:18])[CH:27]=2)=[CH:32][CH:33]=1

Participants

5

Reactant 3

HCID 222416673-(4-methoxybenzyl)-1H-pyrazol-5-amineHCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 1784897533-[[[5-[(4-methoxyphenyl)methyl]-1H-pyrazol-3-yl]amino]methylidene]-1H-indol-2-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 5-(4-methoxy-benzyl)-1H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.041 gms.) is reacted with 0.078 gms. of 5-(4-methoxy-benzyl)-1H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (1.0 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-600b12f4c7dd405689f7acd6faebbdd6
Source dataset
uspto-grants-2006_02
Patent number
US07005444B2

Reaction notes

Loading…