4-fluoro-1H-indazol-3-amine → HCID 178517097, compound

HRID 892029Notes

Reaction equation

HRID 892029 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[F:19][C:20]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:21]=1[C:22]([NH2:29])=[N:23][NH:24]2>O1CCCC1>[F:19][C:20]1[CH:28]=[CH:27][CH:26]=[C:25]2[C:21]=1[C:22]([NH:29][CH:8]=[C:9]1[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]1=[O:18])=[N:23][NH:24]2

Participants

5

Reactant 3

HCID 8179114-fluoro-1H-indazol-3-amineHCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178517097HCID 178517097, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 4-fluoro-1H-indazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.2186 gms. of 4-fluoro-1H-indazol-3-ylamine by refluxing in tetrahydrofuran (2.5 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-623a68437adf437daee49783e0e7fad9
Source dataset
uspto-grants-2006_02
Patent number
US07005444B2

Reaction notes

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