Methyl 4-(3-amino-1H-pyrazol-5-yl)benzoate → HCID 178497538, compound

HRID 892038Notes

Reaction equation

HRID 892038 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[CH3:19][O:20][C:21](=[O:34])[C:22]1[CH:27]=[CH:26][C:25]([C:28]2[NH:29][N:30]=[C:31]([NH2:33])[CH:32]=2)=[CH:24][CH:23]=1>O1CCCC1>[CH3:19][O:20][C:21](=[O:34])[C:22]1[CH:23]=[CH:24][C:25]([C:28]2[NH:29][N:30]=[C:31]([NH:33][CH:8]=[C:9]3[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[NH:11][C:10]3=[O:18])[CH:32]=2)=[CH:26][CH:27]=1

Participants

5

Reactant 3

HCID 57342040Methyl 4-(3-amino-1H-pyrazol-5-yl)benzoateHCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178497538HCID 178497538, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 4-(5-amino-2H-pyrazol-3-yl)-benzoic acid methyl ester for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.2847 gms. of 4-(5-amino-2H-pyrazol-3-yl)-benzoic acid methyl ester by refluxing in tetrahydrofuran (2.5 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-1a1c803f1c9c4c8c84e443235af578dd
Source dataset
uspto-grants-2006_02
Patent number
US07005444B2

Reaction notes

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