3-(furan-2-yl)-1H-pyrazol-5-amine → HCID 178517183, compound

HRID 892041Notes

Reaction equation

HRID 892041 reaction equation
O/[CH:2]=[C:3]1\[C:4](=[O:13])[NH:5][C:6]2[C:11]\1=[CH:10][C:9]([F:12])=[CH:8][CH:7]=2.O/C=C1\C(=O)NC2C\1=CC=CC=2.[NH2:26][C:27]1[CH:31]=[C:30]([C:32]2[O:33][CH:34]=[CH:35][CH:36]=2)[NH:29][N:28]=1.NC1C=CNN=1>O1CCCC1>[F:12][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[NH:5][C:4](=[O:13])[C:3]2=[CH:2][NH:26][C:27]1[CH:31]=[C:30]([C:32]2[O:33][CH:34]=[CH:35][CH:36]=2)[NH:29][N:28]=1

Participants

6

Reactant 4

HCID 5231833-(furan-2-yl)-1H-pyrazol-5-amine2×HCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compoundHCID 178517185(3Z)-5-fluoro-3-(hydroxymethylidene)-1H-indol-2-one2×

Product 1

HCID 178517183HCID 178517183, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-5-fluoro-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and 3-amino-5-(2-furyl)-pyrazole for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-5-fluoro-1,3-dihydro-indol-2-one (0.050 gms.) is reacted with 0.085 gms. of 3-amino-5-(2-furyl)-pyrazole by refluxing in tetrahydrofuran (1.5 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-e9bbdaaf1d5a4230bae43e17985f2521
Source dataset
uspto-grants-2006_02
Patent number
US07005444B2

Reaction notes

Loading…