HCID 178418806, compound → HCID 178424842, compound

HRID 892065Notes

Reaction equation

HRID 892065 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[CH3:19][C:20]1[CH:21]=[C:22]([CH:30]=[CH:31][CH:32]=1)[CH2:23][C:24]1[CH:25]=[C:26]([NH2:29])[NH:27][N:28]=1>O1CCCC1>[CH3:19][C:20]1[CH:21]=[C:22]([CH:30]=[CH:31][CH:32]=1)[CH2:23][C:24]1[CH:25]=[C:26]([NH:29][CH:8]=[C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])[NH:27][N:28]=1

Participants

5

Reactant 3

HCID 178418806HCID 178418806, compoundHCID 178424850HCID 178424850, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178424842HCID 178424842, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 5-(3-methyl-benzyl)-2H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.240 gms. 5-(3-methyl-benzyl)-2H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (2.5 mL) overnight.

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-d8a21947ac394db0867ce0e1f5c58f79
Source dataset
uspto-grants-2006_02
Patent number
US07005444B2

Reaction notes

Loading…