4-Bromo-5-methyl-1,2-oxazol-3-amine → HCID 178435007, compound

HRID 892071Notes

Reaction equation

HRID 892071 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[Br:19][C:20]1[C:21]([NH2:26])=[N:22][O:23][C:24]=1[CH3:25]>O1CCCC1>[Br:19][C:20]1[C:21]([NH:26][CH:8]=[C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])=[N:22][O:23][C:24]=1[CH3:25]

Participants

5

Reactant 3

HCID 27744644-Bromo-5-methyl-1,2-oxazol-3-amineHCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178435007HCID 178435007, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 4-bromo-5-methyl-isoxazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.2211 gms. 4-bromo-5-methyl-isoxazol-3-ylamine by refluxing in tetrahydrofuran (2.7 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-4cc5c8e61915427685577697e76ec256
Source dataset
uspto-grants-2006_02
Patent number
US07005444B2

Reaction notes

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