3-Isoxazolamine → HCID 178517096, compound

HRID 892072Notes

Reaction equation

HRID 892072 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[O:19]1[CH:23]=[CH:22][C:21]([NH2:24])=[N:20]1>O1CCCC1>[O:19]1[CH:23]=[CH:22][C:21]([NH:24][CH:8]=[C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])=[N:20]1

Participants

5

Reactant 3

HCID 18102163-IsoxazolamineHCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178517096HCID 178517096, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting isoxazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.09 mL isoxazol-3-ylamine by refluxing in tetrahydrofuran (2.7 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-ead9667a817b4696aea6e6dc82564699
Source dataset
uspto-grants-2006_02
Patent number
US07005444B2

Reaction notes

Loading…