1-Ethyl-1H-pyrazol-5-amine → HCID 178463040, compound

HRID 892075Notes

Reaction equation

HRID 892075 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[CH2:19]([N:21]1[C:25]([NH2:26])=[CH:24][CH:23]=[N:22]1)[CH3:20]>O1CCCC1>[CH2:19]([N:21]1[C:25]([NH:26][CH:8]=[C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[NH:11][C:10]2=[O:18])=[CH:24][CH:23]=[N:22]1)[CH3:20]

Participants

5

Reactant 3

HCID 3373101-Ethyl-1H-pyrazol-5-amineHCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178463040HCID 178463040, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 2-ethyl-2H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.1632 gms. 2-ethyl-2H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (2.5 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-7f8b8e464e5d492ca25512840b95fd55
Source dataset
uspto-grants-2006_02
Patent number
US07005444B2

Reaction notes

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