HCID 2742258, compound → HCID 178434875, compound

HRID 892076Notes

Reaction equation

HRID 892076 reaction equation
NC1C=CNN=1.O/[CH:8]=[C:9]1\[C:10](=[O:18])[NH:11][C:12]2[C:17]\1=[CH:16][CH:15]=[CH:14][CH:13]=2.[C:19]([C:23]1[O:27][C:26]([CH3:28])=[C:25]([C:29]2[CH:30]=[C:31]([NH2:35])[N:32]([CH3:34])[N:33]=2)[CH:24]=1)([CH3:22])([CH3:21])[CH3:20]>O1CCCC1>[C:19]([C:23]1[O:27][C:26]([CH3:28])=[C:25]([C:29]2[CH:30]=[C:31]([NH:35][CH:8]=[C:9]3[C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[NH:11][C:10]3=[O:18])[N:32]([CH3:34])[N:33]=2)[CH:24]=1)([CH3:22])([CH3:20])[CH3:21]

Participants

5

Reactant 3

HCID 2742258HCID 2742258, compoundHCID 178418806HCID 178418806, compoundHCID 178517101HCID 178517101, compound

Product 1

HCID 178434875HCID 178434875, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting 5-(5-tert-butyl-2-methyl-furan-3-yl)-2-methyl-2H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one (0.100 gms.) is reacted with 0.2377 gms. 5-(5-tert-butyl-2-methyl-furan-3-yl)-2-methyl-2H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (2.5 mL).

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

Sources & evidence

ORD record
ord-0c0a1d51193e4316814c5aba7ba4c11d
Source dataset
uspto-grants-2006_02
Patent number
US07005444B2

Reaction notes

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