HCID 178418806, compound → HCID 178434877, compound

HRID 892081Notes

Reaction equation

HRID 892081 reaction equation
O/[CH:2]=[C:3]1\[C:4](=[O:13])[NH:5][C:6]2[C:11]\1=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=2.O/C=C1\C(=O)NC2C\1=CC=CC=2.[C:26]([C:30]1[O:34][C:33]([CH3:35])=[C:32]([C:36]2[CH:37]=[C:38]([NH2:41])[NH:39][N:40]=2)[CH:31]=1)([CH3:29])([CH3:28])[CH3:27].NC1C=CNN=1>O1CCCC1>[C:26]([C:30]1[O:34][C:33]([CH3:35])=[C:32]([C:36]2[CH:37]=[C:38]([NH:41][CH:2]=[C:3]3[C:11]4[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=4)[NH:5][C:4]3=[O:13])[NH:39][N:40]=2)[CH:31]=1)([CH3:29])([CH3:27])[CH3:28]

Participants

6

Reactant 4

HCID 178418806HCID 178418806, compoundHCID 178434878HCID 178434878, compound2×HCID 178517101HCID 178517101, compoundHCID 178517312(3Z)-6-fluoro-3-(hydroxymethylidene)-1H-indol-2-one2×

Product 1

HCID 178434877HCID 178434877, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-6-fluoro-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and 5-(5-tert-butyl-2-methyl-furan-3-yl)-2H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-6-fluoro-1,3-dihydro-indol-2-one (0.033 gms.) is reacted with 0.089 gms. 5-(5-tert-butyl-2-methyl-furan-3-yl)-2H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (0.88 mL) to afford the named compound in the amount of 0.0362 gms.

Workup

  1. customThe named compound is prepared
  2. customin the reaction of Example 1
  3. customto afford the named compound in the amount of 0.0362 gms

Sources & evidence

ORD record
ord-5fab670c35da4f3c800256f91d14ee29
Source dataset
uspto-grants-2006_02
Patent number
US07005444B2

Reaction notes

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