Dimethylamine → HCID 23600532, compound

HRID 892273Notes

Reaction equation

HRID 892273 reaction equation
C([O:3][C:4]([N:6]1[CH2:11][CH2:10][C:9]([CH2:17][NH:18][C:19](=[O:28])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[O:26][CH3:27])([C:12]2S[CH:14]=[CH:15][CH:16]=2)[CH2:8][CH2:7]1)=O)C.[CH3:29][NH:30][CH3:31].O1CC[CH2:34][CH2:33]1>>[CH3:29][N:30]([CH3:31])[C:4]([N:6]1[CH2:7][CH2:8][C:9]([CH2:17][NH:18][C:19](=[O:28])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[O:26][CH3:27])([C:12]2[CH:34]=[CH:33][CH:14]=[CH:15][CH:16]=2)[CH2:10][CH2:11]1)=[O:3]

Participants

4

Reactant 3

HCID 674DimethylamineHCID 8028TetrahydrofuranHCID 23600788HCID 23600788, compound

Product 1

HCID 23600532HCID 23600532, compound

Conditions

Temperature
65 °C

Procedure

Compound 2 (0.050 g; 0.10 mmol) was treated with 2 M dimethylamine in tetrahydrofuran (2 mL) and heated to 65° C. in a sealed tube for 12 h. The solvent was removed by rotary evaporation and the crude residue was purified by preparative reverse phase HPLC to give 0.018 g of the title compound as a white solid. LRMS m/z 396 (M+H)+.

Workup

  1. customThe solvent was removed by rotary evaporation
  2. customthe crude residue was purified by preparative reverse phase HPLC

Sources & evidence

ORD record
ord-89add8804fa748078eb7b715fd3ece85
Source dataset
uspto-grants-2006_02
Patent number
US07005436B2

Reaction notes

Loading…