Methanesulfonamide → HCID 10302452, compound

HRID 892289Notes

Reaction equation

HRID 892289 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:20])[C:10]=1[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Br:19])[CH:14]=1)[C:5](O)=[O:6].[CH3:21][S:22]([NH2:25])(=[O:24])=[O:23]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:20])[C:10]=1[O:11][CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Br:19])[CH:14]=1)[C:5]([NH:25][S:22]([CH3:21])(=[O:24])=[O:23])=[O:6]

Participants

3

Reactant 2

HCID 72879MethanesulfonamideHCID 22242280HCID 22242280, compound

Product 1

HCID 10302452HCID 10302452, compoundYield 67.6%

Procedure

3,5-Dibromo-4-(3-bromobenzyloxy)benzoic acid (0.15 mmol) was coupled with methanesulphonamide (0.77 mmol) using the procedure described in Example 31. Purification on column (silica gel, chloroform/methanol 9:1) gave 55 mg (67%) of N-[3,5-dibromo-4-(3-bromobenzyloxy)benzoyl]methanesulphonamide.

Workup

  1. customPurification on column (silica gel, chloroform/methanol 9:1)

Sources & evidence

ORD record
ord-2b50343f36e0475596f24901e51f6c08
Source dataset
uspto-grants-2006_02
Patent number
US07005538B1

Reaction notes

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