反应详情

To 1-(4-methoxy-phenyl)-7-oxo-6-[4-(2-oxo-2H-pyridin-1-yl)-phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester (0.2 g, 0.4 mmol) in THF (25 mL) was added 2M LiBH4 in THF (0.31 mL, 0.66 mmol) and the reaction was heated to reflux for 3 h. After extraction into EtOAc and washing with water and brine, the product crystallized out upon standing; High Resolution Mass Spec (M+H)+ for C25H23N4O4 443.1730.

1. temperaturethe reaction was heated
2. temperatureto reflux for 3 h
3. extractionAfter extraction into EtOAc
4. washwashing with water and brine
5. customthe product crystallized out