Acetic Acid → 2-methyl-1H-benzimidazole-5-carboxylic acid

HRID 892341Notes

Reaction equation

HRID 892341 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[NH2:11])[C:5]([OH:7])=[O:6].[C:12](O)(=O)[CH3:13]>Cl>[CH3:12][C:13]1[NH:11][C:10]2[CH:9]=[CH:8][C:4]([C:5]([OH:7])=[O:6])=[CH:3][C:2]=2[N:1]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 692633,4-Diaminobenzoic acid

Product 1

HCID 11326092-methyl-1H-benzimidazole-5-carboxylic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

100 g (0.657 mol) of 3,4-diaminobenzoic acid are boiled under reflux with 47.3 g (0.788 mol) of glacial acetic acid and 600 ml of 4N HCl in analogy to Example 14a.

Sources & evidence

ORD record
ord-2fd7ec442d5b4246be5231cfd0fbd634
Source dataset
uspto-grants-1992_06
Patent number
USRE033948

Reaction notes

Loading…