反应详情

A stirred solution of 6-amino-2-(2-propoxyphenyl)-pyrimidin-4[3H]-one (0.68 g) and n-butyric anhydri was heated at 140° C. for 5 hours. Ethanol was added to the cooled reaction mixture which was then evaporated under reduced pressure to yield a residue which was azeotroped and washed with water. The residue was eluted from silica with chloroform and the combined fractions containing product were evaporated under reduced pressure to yield a crude product which was recrystallised from isopropanol: diethyl ether to yield the title compound, 0.21 g, m.p. 177°-8° C.

1. customwas then evaporated under reduced pressure
2. customto yield a residue which
3. customwas azeotroped
4. washwashed with water
5. washThe residue was eluted from silica with chloroform
6. additionthe combined fractions containing product
7. customwere evaporated under reduced pressure
8. customto yield a crude product which
9. customwas recrystallised from isopropanol