6-Amino-2-(2-propoxyphenyl)pyrimidin-4[3H]-one → 6-Butyramido-2-(2-propoxyphenyl)pyrimidin-4[3H1 one

Participants

Reaction Steps

A stirred solution of 6-amino-2-(2-propoxyphenyl)-pyrimidin-4[3H]-one (0.68 g) and n-butyric anhydri was heated at 140° C. for 5 hours. Ethanol was added to the cooled reaction mixture which was then evaporated under reduced pressure to yield a residue which was azeotroped and washed with water. The residue was eluted from silica with chloroform and the combined fractions containing product were evaporated under reduced pressure to yield a crude product which was recrystallised from isopropanol: diethyl ether to yield the title compound, 0.21 g, m.p. 177°-8° C.

Provenance & Evidence