反应详情

406 mg of m-chloroperbenzoic acid were added to a solution of 528 mg of 3,4-dihydro-2,2-dimethyl-4-(2-pyridyl)-2H-1-benzopyran-6-carbonitrile in 15 ml of dichloromethane at room temperature. After 2 hours at room temperature the mixture was washed with sodium bicarbonate solution and the organic phase was dried over sodium sulphate and evaporated. The residue crystallized from t-butyl methyl ether and was recrystallized from toluene to give 360 mg of 2-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)pyridine N-oxide of melting point 158°-160° C.

1. washAfter 2 hours at room temperature the mixture was washed with sodium bicarbonate solution
2. dry with materialthe organic phase was dried over sodium sulphate
3. customevaporated
4. customThe residue crystallized from t-butyl methyl ether
5. customwas recrystallized from toluene