2,2-dimethyl-4-(2-quinolyl)-2H-1-benzopyran-6-carbonitrile → HCID 19895666、化合物

HRID 892594ノート

反応式

HRID 892594 の反応式
[CH3:1][C:2]1([CH3:24])[CH:7]=[C:6]([C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)[C:5]2[CH:18]=[C:19]([C:22]#[N:23])[CH:20]=[CH:21][C:4]=2[O:3]1>C(O)C.[Pd]>[CH3:1][C:2]1([CH3:24])[CH2:7][CH:6]([C:8]2[CH:17]=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[N:9]=2)[C:5]2[CH:18]=[C:19]([C:22]#[N:23])[CH:20]=[CH:21][C:4]=2[O:3]1

参加物

4

反応物 1

HCID 198956232,2-dimethyl-4-(2-quinolyl)-2H-1-benzopyran-6-carbonitrile

生成物 1

HCID 19895666HCID 19895666、化合物収率 65.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

624 mg of 2,2-dimethyl-4-(2-quinolyl)-2H-1-benzopyran-6-carbonitrile were shaken at room temperature under a hydrogen atmosphere in 25 ml of ethanol with 50 mg of 10% palladium-on-charcoal. After 4 hours the mixture was filtered and the filtrate was evaporated. The residue was chromatographed on silica gel using ethyl acetate/petroleum ether (1:2) for the elution. The product was recrystallized from isopropanol to give 410 mg of 3,4-dihydro-2,2-dimethyl-4-(2-quinolyl)-2H-1-benzopyran-6-carbonitrile of melting point 174°-176° C.

後処理

  1. filtrationAfter 4 hours the mixture was filtered
  2. customthe filtrate was evaporated
  3. customThe residue was chromatographed on silica gel
  4. washfor the elution
  5. customThe product was recrystallized from isopropanol

出典と根拠

ORDレコード
ord-e02512e3c1494a1e99425016b0717698
出典データセット
uspto-grants-1992_06
特許番号
US05118694

反応ノート

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