Hydrochloric Acid → HCID 28789692, compound

Participants

Reaction Steps

To a solution of N-[(2-oxo-1-pyrrolidinyl)acetyl]-L-proline methyl ester (5.06 g) in methanol (40 ml) was added dropwise a 2N sodium hydroxide solution (12 ml) under ice-cooling, and the mixture was stirred at room temperature for 3 hours. To the reaction mixture was added 3N hydrochloric acid under ice-cooling to adjust the mixture to pH 5. The reaction mixture was concentrated to dryness, suspended in chloroform and filtered. The filtrate was concentrated to give 4.28 g of N-[(2-oxo-1-pyrrolidinyl)acetyl]-L-proline.

Provenance & Evidence