Hydrochloric Acid → HCID 28789692, compound

HRID 892605Notes

Reaction equation

HRID 892605 reaction equation
C[O:2][C:3](=[O:18])[C@@H:4]1[CH2:8][CH2:7][CH2:6][N:5]1[C:9](=[O:17])[CH2:10][N:11]1[CH2:15][CH2:14][CH2:13][C:12]1=[O:16].[OH-].[Na+].Cl>CO>[O:16]=[C:12]1[CH2:13][CH2:14][CH2:15][N:11]1[CH2:10][C:9]([N:5]1[CH2:6][CH2:7][CH2:8][C@H:4]1[C:3]([OH:18])=[O:2])=[O:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54370671HCID 54370671, compound

Product 1

HCID 28789692HCID 28789692, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of N-[(2-oxo-1-pyrrolidinyl)acetyl]-L-proline methyl ester (5.06 g) in methanol (40 ml) was added dropwise a 2N sodium hydroxide solution (12 ml) under ice-cooling, and the mixture was stirred at room temperature for 3 hours. To the reaction mixture was added 3N hydrochloric acid under ice-cooling to adjust the mixture to pH 5. The reaction mixture was concentrated to dryness, suspended in chloroform and filtered. The filtrate was concentrated to give 4.28 g of N-[(2-oxo-1-pyrrolidinyl)acetyl]-L-proline.

Workup

  1. temperaturecooling
  2. temperaturecooling
  3. concentrationThe reaction mixture was concentrated to dryness
  4. filtrationfiltered
  5. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-686af426e75d491f9eb4859490a86ec4
Source dataset
uspto-grants-1992_06
Patent number
US05118811

Reaction notes

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